Comparison of Micellar Electrokinetic Chromatography, Liquid Chromatography, and Microbiologic Assay for Analysis of Cephalexin in Oral Suspensions

Micellar electrokinetic chromatography.

Analysis of oseltamivir in Tamiflu capsules using micellar electrokinetic chromatography.

A simple and rapid micellar electrokinetic chromatography (MEKC) method was developed for the analysis of an antiviral drug, oseltamivir, and its hydrolyzed product in Tamiflu capsules. Background electrolytes consisted of boric acid 10 mM, pH 10, and sodium dodecyl sulphate (SDS) 40 mM. The limit of detection (LOD) and limit of quantification (LOQ) of oseltamivir were 1.7 and 8.0 microg/ml, re...

Twenty-five years of micellar electrokinetic chromatography

Micellar electrokinetic chromatography (MEKC), which can separate neutral analytes as well as charged analytes by the capillary electrophoretic technique, was developed in 1982 and the first paper was published in 1984. The authors’ group concentrated their effort into the characterization of MEKC as a separation technique until early 1990s. Most issues in MEKC separations were successfully sol...

Principles of micellar electrokinetic capillary chromatography applied in pharmaceutical analysis.

Since its introduction capillary electrophoresis has shown great potential in areas where electrophoretic techniques have rarely been used before, including here the analysis of pharmaceutical substances. The large majority of pharmaceutical substances are neutral from electrophoretic point of view, consequently separations by the classic capillary zone electrophoresis; where separation is base...

Retention indices in micellar electrokinetic chromatography

The use o f retent ion indices in mice l la r electrokinet ic ch roma tog raphy ( M E K C ) is eva lua ted both f rom a theoretical and a practical point o f view. F undamen t a l equa t ions for the de te rmina t ion o f retent ion indices in M E K C are descr ibed, showing that re tent ion indices are independen t o f the surfac tant concentra t ion. Possibi l i t ies as well as l imita t ion...